1,734 Artículos relativos a Prodrogas

• Ethylene dibromide and disulfiram: studies in vivo and in vitro on the mechanism of the observed synergistic carcinogenic response.
  Publicado en Carcinogenesis
• Patients with essential hypertension have an exaggerated natriuretic response to the dopamine pro-drug glutamyl-dopa.
  Publicado en J Hypertens Suppl
• Effect of substrate concentration, product concentration, and peptides on the in vitro hydrolysis of model ester prodrugs by corneal esterases.
  Publicado en J Ocul Pharmacol
• Triazene metabolism. V. Chemical and biological properties of N,N-bis-[(1-aryl-3-methyltriazen-3-yl)-methyl]-methylamines: potential prodrugs for the cytotoxic monomethyltriazenes.
  Publicado en Anticancer Drug Des
• Triazene metabolism. IV. Derivatives of hydroxymethyltriazenes: potential prodrugs for the active metabolites of the anti-tumour triazene, DTIC.
  Publicado en Anticancer Drug Des
• Effects of ibuterol, a beta-2 adrenergic prodrug, on intraocular pressure.
  Publicado en J Ocul Pharmacol
• Design and rationale for novel antifolates.
  Publicado en NCI Monogr
• Multivariate statistical analysis of L-dopa esters as potential anti-parkinsonian prodrugs.
  Publicado en Drug Des Deliv
• GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid.
  Publicado en Drug Des Deliv
• Effect of dose and food on the bioavailability of cefuroxime axetil.
  Publicado en Biopharm Drug Dispos
• Antibody directed enzymes revive anti-cancer prodrugs concept.
  Publicado en Br J Cancer
• Early adventures in drug metabolism: 4. Diphenylhydantoin (phenytoin).
  Publicado en Ther Drug Monit
• N-Mannich-base prodrugs of 5-iodo-2'-deoxycytidine as topical delivery enhancers.
  Publicado en Pharm Res
• Disposition and tumor localization of mitomycin C-dextran conjugates in mice.
  Publicado en Pharm Res
• N-(2-cyanoethyl)tranylcypromine, a potential prodrug of tranylcypromine: its disposition and interaction with catecholamine neurotransmitters in brain.
  Publicado en Pharm Res
• Metodika otsenki soderzhaniia provitaminov gruppy D v drozhzhakh Saccharomyces cerevisiae s izmenennym metabolizmom sterinov.
  Publicado en Prikl Biokhim Mikrobiol
• Hemodynamic effects of a new angiotensin converting enzyme inhibitor, spirapril, in sodium-loaded and sodium-depleted rabbits.
  Publicado en J Cardiovasc Pharmacol
• L-dopa esters as potential prodrugs: effect on brain concentration of dopamine metabolites in reserpinized mice.
  Publicado en J Pharm Pharmacol
• Adenosine analogs with covalently attached lipids have enhanced potency at A1-adenosine receptors.
  Publicado en FEBS Lett
• Kinetics and dynamics of prednisolone.
  Publicado en Endocr Rev
• Treatment of experimental cytomegalovirus infections with acyclovir.
  Publicado en Arch Virol
• Metabolism of desciclovir, a prodrug of acyclovir, in humans after multiple oral dosing.
  Publicado en J Clin Pharmacol
• Efficacy and tolerability of cefuroxime axetil in patients with upper respiratory tract infections.
  Publicado en Curr Med Res Opin
• Polymeric prodrugs.
  Publicado en Crit Rev Ther Drug Carrier Syst
• Neuropharmacological and neurochemical properties of N-(2-cyanoethyl)-2-phenylethylamine, a prodrug of 2-phenylethylamine.
  Publicado en Br J Pharmacol
• Pharmacokinetics and tolerance of desciclovir, a prodrug of acyclovir, in healthy human volunteers.
  Publicado en Antimicrob Agents Chemother
• Fasciola hepatica in vitro: increased susceptibility to fasciolicides in a defined serum-free medium.
  Publicado en Parasitology
• Liposomen als Träger von lipophilen Cytosinarabinosid- und Fluorodeoxyuridin-Derivaten. Ihre zytostatische Wirkung und Möglichkeiten zur tumorzellspezifischen Therapie.
  Publicado en Onkologie
• Metabolic synthesis of arylacetic acid antiinflammatory drugs from arylhexenoic acids. 2. Indomethacin.
  Publicado en J Med Chem
• Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.
  Publicado en J Med Chem
• Enhanced antitumor activity of 5'-deoxy-5-fluorouridine against Lewis lung carcinoma in aged hybrid (C57BL/6 x DBA/2) F1 mice.
  Publicado en J Pharmacobiodyn
• Cefuroxime axetil in acute purulent exacerbations of chronic bronchitis.
  Publicado en Infection
• Purin-6-yl 6-deoxy-1-thio-beta-D-glucopyranoside. Enzymology, chemistry, and cytotoxicity.
  Publicado en Carbohydr Res
• Evaluation of (+)-cyclaradine-5'-esters as prodrugs for (+)-cyclaradine in animals.
  Publicado en Antimicrob Agents Chemother
• Podavlenie butilgidroksitoluolom mutagennogo deistviia kantserogennykh nitrozosoedinenii i tsiklofosfana: rol' reaktsii kon''iugatsii s glutationom.
  Publicado en Vopr Onkol
• Metodika kolichestvennogo opredeleniia delta 5,7-sterinov v neomyliaemykh lipidnykh fraktsiiakh.
  Publicado en Prikl Biokhim Mikrobiol
• Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.
  Publicado en J Med Chem
• N,N-dipropargyl-2-phenylethylamine, a potential prodrug of 2-phenylethylamine: neurochemical and neuropharmacological studies in rat.
  Publicado en Brain Res Bull
• Bambuterol- a prodrug-prodrug with built-in hydrolysis brake.
  Publicado en Acta Pharm Suec
• Evaluation of Plasmodium falciparum-microsomal in vitro system for testing pro-drugs.
  Publicado en Indian J Med Res
• Deconvolution analysis of the regeneration process of mitomycin C from prodrug in a muscle perfusion system based on statistical moment theory.
  Publicado en Chem Pharm Bull (Tokyo)
• Disposition characteristics of lipophilic mitomycin C prodrug in an intra-arterial muscle infusion system.
  Publicado en Chem Pharm Bull (Tokyo)
• Biological activities of 5-fluorouracil and its prodrug 5'-deoxy-5-fluorouridine in rats.
  Publicado en Cancer Drug Deliv
• Prodrugs as drug delivery systems. 74. Facile hydrolysis of N-(acyloxymethyl)amide derivatives and implications for the design of prodrugs of NH-acidic compounds and of carboxylic acids.
  Publicado en Acta Pharm Suec
• Triazene metabolism. VI. 3-Azidomethyl-3-alkyl-1-aryltriazenes, a new class of anti-tumour triazene with potential pro-drug applications.
  Publicado en Anticancer Drug Des
• Effects of vehicles and prodrug properties and their interactions on the delivery of 6-mercaptopurine through skin: bisacyloxymethyl-6-mercaptopurine prodrugs.
  Publicado en J Pharm Sci
• Disposition and availability of 5-fluorouracil prodrug 5'-deoxy-5-fluorouridine after oral administration in rats.
  Publicado en J Pharm Sci
• Effects of spiraprilic acid, an angiotensin converting enzyme inhibitor, on large artery compliance in anesthetized dogs.
  Publicado en Arch Int Pharmacodyn Ther
• Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir.
  Publicado en Acta Chem Scand B
• Recent advances in non-steroid anti-inflammatory drugs.
  Publicado en Drugs Exp Clin Res
• Some perspectives on targeted delivery with prodrugs.
  Publicado en Ann N Y Acad Sci
• Hydrolysis kinetics of diacetyl nadolol.
  Publicado en J Pharm Sci
• N4-chloroacetylcytosine arabinoside--a possible pro-drug of cytosine arabinoside.
  Publicado en Biochem Int
• Cellular interaction and in vitro antitumor effect of various mitomycin C prodrugs in mitomycin C-resistant L1210 leukemia cell lines.
  Publicado en Chem Pharm Bull (Tokyo)
• Cellular interaction and in vitro antitumor activity of lipophilic mitomycin C prodrugs.
  Publicado en Chem Pharm Bull (Tokyo)
• Bambuterol, a carbamate ester prodrug of terbutaline, as inhibitor of cholinesterases in human blood.
  Publicado en Drug Metab Dispos
• Comparative study on the disposition of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine hydrochloride in rats and dogs.
  Publicado en Drug Metab Dispos
• Metabolism of the prodrug DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide) to the potent anticonvulsant LY201116 in mice. Effect of bis-(p-nitrophenyl)phosphate.
  Publicado en Drug Metab Dispos
• Ocular absorption and disposition of phenylephrine and phenylephrine oxazolidine.
  Publicado en Biopharm Drug Dispos
• A cytotoxic agent can be generated selectively at cancer sites.
  Publicado en Br J Cancer
• Pharmacological profiles of CS-622, a novel angiotensin converting enzyme inhibitor.
  Publicado en Jpn J Pharmacol
• Basis and new developments in the field of oxazaphosphorines.
  Publicado en Cancer Invest
• New prodrugs of acyclic nucleosides with antiviral activity.
  Publicado en Arzneimittelforschung
• Structure and conformation of 3'-O-acetyl-2'-deoxy-5-methoxymethyluridine.
  Publicado en Acta Crystallogr C
• Inhibition of cell proliferation with antibody-targeted liposomes containing methotrexate-gamma-dimyristoylphosphatidylethanolamine.
  Publicado en Biochim Biophys Acta
• Selective inhibition of cholesterol side-chain cleavage by potential pro-drug forms of aminoglutethimide.
  Publicado en Anticancer Drug Des
• Bambuterol: clinical effects of three doses of bambuterol once daily in asthmatic patients.
  Publicado en Allergy
• Preparación y caracterización de pro-fármacos del praziquantel potencialmente esquistosomicidas.
  Publicado en Acta Cient Venez
• Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat.
  Publicado en J Pharmacol Exp Ther
• Stereoselective synthesis of (1-alkoxyalkyl) alpha- and beta-D-glucopyranosiduronates (acetal-glucopyranosiduronates): a new approach to specific cytostatics for the treatment of cancer.
  Publicado en Carbohydr Res
• The effect of lithium on the renal response to the dopamine prodrug gludopa in normal man.
  Publicado en Br J Clin Pharmacol
• Acitrétine (RO 10-1670). Un successeur de l'étrétinate?.
  Publicado en Ann Dermatol Venereol
• Bioavailability and newer methods of delivery of phosphorothioate radioprotectors.
  Publicado en Pharmacol Ther
• The antitumour effect of lipophilic derivatives of 5-fluoro-2'-deoxyuridine incorporated into liposomes.
  Publicado en J Microencapsul
• Synthesis and biological activity of a new cephalosporin, BMY-28232 and its prodrug-type esters for oral use.
  Publicado en J Antibiot (Tokyo)
• Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro.
  Publicado en Biochem Pharmacol
• The influence of bambuterol (carbamylated terbutaline) on the duration of action of succinylcholine-induced paralysis in humans.
  Publicado en Anesthesiology
• The contribution of enantiomers to variability in response to anti-inflammatory drugs.
  Publicado en Agents Actions Suppl
• Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity.
  Publicado en Neurosci Lett
• Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856).
  Publicado en J Med Chem
• N-sulfonyl imidates as a novel prodrug form for an ester function or a sulfonamide group.
  Publicado en J Med Chem
• Evaluation of enkephalinase inhibition in the living mouse, using [3H]acetorphan as a probe.
  Publicado en J Pharmacol Exp Ther
• Time course of the antibacterial activity of erythromycin stearate and erythromycin acistrate against two Staphylococcus aureus strains in vitro.
  Publicado en J Antimicrob Chemother
• Cefuroxime axetil.
  Publicado en J Antimicrob Chemother
• Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol.
  Publicado en Curr Eye Res
• New possibilities for the beta-adrenoceptor agonist bronchodilator drugs.
  Publicado en Agents Actions Suppl
• Bambuterol, a bronchodilator prodrug with sustained action, enhances delivery of active drug to the lung.
  Publicado en Agents Actions Suppl
• Proconvulsant and 'anxiogenic' effects of n-butyl beta carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain.
  Publicado en Pharmacol Biochem Behav
• Glycine involvement in DDT-induced myoclonus.
  Publicado en Mov Disord
• Synthesis and biological evaluation of isomeric dinucleoside monophosphates and monomethylphosphonates of 9-beta-D-arabinofuranosyladenine and related analogues.
  Publicado en J Med Chem
• Potential prodrugs of phenelzine: N2-acetylphenelzine and N2-ethoxycarbonylphenelzine.
  Publicado en J Pharm Sci
• Comparison of salicylamide and acetaminophen and their prodrug disposition in dogs.
  Publicado en J Pharmacobiodyn
• Influence of corneal epithelial integrity on the penetration of timolol prodrugs.
  Publicado en J Ocul Pharmacol
• Simultaneous determination of the prodrug zofenopril and its active drug in plasma by capillary gas chromatography-mass-selective detection.
  Publicado en J Chromatogr
• NIH conference. Cystinosis: progress in a prototypic disease.
  Publicado en Ann Intern Med
• Prodrug behaviour of nicotinoylmorphine esters.
  Publicado en J Pharm Pharmacol
• The glycine-prodrug, milacemide, increases the seizure threshold due to hyperbaric oxygen; prevention by 1-deprenyl.
  Publicado en Eur J Pharmacol
• Absorption of tranexamic acid as a prodrug in healthy volunteers.
  Publicado en Arzneimittelforschung
• On the design of urokinase labile prodrugs. Effects of surfactants on surface adsorption of urokinase and comparison of methods for the determination of KM and kcat.
  Publicado en Acta Pharm Suec
• Macromolecular prodrugs. IX. The release kinetics of metronidazole from various dextran dicarboxylic acid hemiester conjugates in aqueous buffer, human plasma and in pig liver homogenate.
  Publicado en Acta Pharm Suec