Título alternativo: [Effects of nifuroxazide on fecal flora in healthy subjects]

Resumen: Effect of nifuroxazide on fecal flora was studied in 12 healthy volunteers receiving, in hazardous order and double-blind procedure, three six-days courses of treatment separated by eight-days spaces of time: the conventional dosage of 400 mg twice a day, a dosage of 1200 mg once a day, and placebo. Among six settled bacteriological index (wealth of the fecal flora, percentage of gram-negative bacteria, numbers of E. coli, Enterococcus, Clostridium and Bacteroides), no significant variation was found by means of statistical study between D0, D2 and D7, nor between the three courses of treatment. Therefore nifuroxazide, even in high dosage, does not injure integrity of microbial intestinal ecosystem under so defined experimental conditions, similar with clinical conditions.

Autor/es: Buisson Y - Larribaud J

Publicado en: Therapie (44(2):123-6, 1989 Mar-Apr.)

ISSN: 0040-5957

Tipo/s de publicación/es: CLINICAL TRIAL - ENGLISH ABSTRACT - JOURNAL ARTICLE - RANDOMIZED CONTROLLED TRIAL

Año de publicación: 1989

País: Francia

Idioma/s: Francés

Descriptor/es: Adulto - Agentes Antibacterianos - Recuento de Colonia Microbiana - Heces - Femenino - Humanos - Ácidos Hidroxibenzoicos - Masculino - Nitrofuranos - Factores de Tiempo

Substancia/s: 0 (Anti-Bacterial Agents) - 0 (Hydroxybenzoic Acids) - 0 (Nitrofurans) - 965-52-6 (nifuroxazide)